Daniel Calabrese, MD

Asst Professor in Residence
Medicine
+1 415 476-0735

Dr. Calabrese is an Assistant Professor of Medicine at UCSF and a Staff Physician at the San Francisco VA Medical Center. He received his undergraduate degree from Washington University in St. Louis and completed his MD at Case Western Reserve University School of Medicine.

He serves as an attending physician in the intensive care unit, pulmonary consult service and outpatient pulmonary clinic at the SF VAMC. He is also an attending physician for the Advanced Lung Disease Service at UCSF Parnassus where he evaluates patients in the lung transplant clinics. He is active in the International Society for Heart and Lung Transplantation.

His research focuses on the mechanisms for innate immune inflammation in lung transplant outcomes. This research uses mouse models of human lung disease and human tissue samples to understand primary graft dysfunction, antibody-mediated rejection and chronic lung allograft dysfunction. The goal of this work is to improve outcomes following lung transplantation.

Publications: 

The Emperor Has Some Clothes: Emerging Molecular Diagnostics in Post-Lung Transplant Decision Making.

American journal of respiratory and critical care medicine

Calabrese DR, Shaver CM

Macrophage and CD8 T Cell Discordance are Associated with Acute Lung Allograft Dysfunction Progression.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Calabrese DR, Yellamilli S, Ekstrand C, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR

Disturbed sleep is associated with worse patient-reported outcomes and chronic lung allograft dysfunction after lung transplantation.

medRxiv : the preprint server for health sciences

Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Greenland JR, Singer JP

MICB Genomic Variant is Associated with NKG2D-mediated Acute Lung Injury and Death.

American journal of respiratory and critical care medicine

Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR, LTOG Investigators

CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.

JCI insight

Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden J, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR

Short Airway Telomeres are Associated with Primary Graft Dysfunction and Chronic Lung Allograft Dysfunction.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ

Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis.

Transplantation direct

Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR

Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Calabrese DR, Greenland JR

The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation.

Transplantation

Singer JP, Gao Y, Huang CY, Kordahl RC, Sriram A, Hays SR, Kukreja J, Venado A, Calabrese DR, Greenland JR

Regadenoson is all the RAGE: Targeting the inflammatory cascade in Primary Graft Dysfunction.

The Annals of thoracic surgery

Bromberger B, Calabrese DR, Brzezinski M, Kukreja J

Development of the Lung Transplant Frailty Scale (LT-FS).

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Zaleski D, Adler J, Kalman L, Balar P, Patel S, Medikonda N, Koons B, Tevald M, Covinsky KE, Greenland JR, Katz PK

Subphenotypes of frailty in lung transplant candidates.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard L LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD

Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein AB, Singer JP, Hays SR

Design and Implementation of a Digital Health Home Spirometry Intervention for Remote Monitoring of Lung Transplant Function.

The Journal of Heart and Lung Transplantation

Anobel Y. Odisho, Andrew W. Liu, Ali R. Maiorano, M. Olivia A. Bigazzi, Eli Medina, Lorriana E. Leard, Rupal Shah, Aida Venado, Alyssa Perez, Jeffrey Golden, Mary Ellen Kleinhenz, Nicholas A. Kolaitis, Julia Maheshwari, Binh N. Trinh, Jasleen Kukreja, John Greenland, Daniel Calabrese, Aaron B. Neinstein, Jonathan P. Singer, Steven R. Hays

The Lung Allocation Score Remains Inequitable for Patients with PAH, Even After the 2015 Revision.

American journal of respiratory and critical care medicine

Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T

CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR

Frailty and genetic risk predict fracture after lung transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Macrae TA, Lazo J, Viduya J, Florez R, Dewey K, Gao Y, Singer JP, Hays SR, Golden JA, Kukreja J, Greenland JR, Calabrese DR

NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.

JCI insight

Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR

Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FceRI? expression.

The Journal of experimental medicine

Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL

Lymphocytic Airway Inflammation in Lung Allografts.

Frontiers in immunology

Santos J, Calabrese DR, Greenland JR

Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression.

The Journal of clinical investigation

Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Mendez-Ferrer S, Swirski FK, Looney MR

Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival.

Clinical transplantation

Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR

Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR

Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.

Frontiers in immunology

Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR

Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates.

Annals of the American Thoracic Society

Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP

Implementation of a Chatbot Mobile Health Intervention with Home Spirometry to Monitor Lung Transplant Recipients Remotely.

The Journal of Heart and Lung Transplantation

A. Odisho, J.P. Singer, A. Perez, L.E. Leard, R. Shah, J.A. Golden, M. Kleinhenz, N. Kolaitis, J. Maheshwari, A. Liu, B. Trinh, J. Kukreja, J. Greenland, D. Calabrese, S.R. Hays

Measuring Quality in Lung Transplant Care: The QUILT Initiative.

The Journal of Heart and Lung Transplantation

A. Venado, J.P. Singer, L.E. Leard, R. Shah, M.E. Kleinhenz, J. Golden, A. Perez, N. Kolaitis, D. Calabrese, J. Maheshwari, B. Trinh, J. Kukreja, S. Hays

Rapid Molecular Detection of Airway Pathogens in Lung Transplant Recipients.

Transplant infectious disease : an official journal of the Transplantation Society

Hoover J, Mintz MA, Deiter F, Aminian E, Chen J, Hays SR, Singer JP, Calabrese DR, Kukreja J, Greenland JR

Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.

The Journal of clinical investigation

Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Hoover J, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger DT, Nakamura M, Lanier LL, Looney MR, Greenland JR

Complement activation on endothelium initiates antibody-mediated acute lung injury.

The Journal of clinical investigation

Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR

Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.

Thorax

Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD, Singer JP

Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP

Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death.

JCI insight

Calabrese DR, Wang P, Chong T, Hoover J, Singer JP, Torgerson D, Hays SR, Golden JA, Kukreja J, Dugger D, Christie JD, Greenland JR

NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.

Transplantation

Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR

Natural killer cells in lung transplantation.

Thorax

Calabrese DR, Lanier LL, Greenland JR

Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.

Clinical transplantation

Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR

HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R

Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings.

Schizophrenia research

Calabrese DR, Wang L, Harms MP, Ratnanather JT, Barch DM, Cloninger CR, Thompson PA, Miller MI, Csernansky JG

Planar relationships of the semicircular canals in two strains of mice.

Journal of the Association for Research in Otolaryngology : JARO

Calabrese DR, Hullar TE